Sign Out
No clinically relevant interactions with Desloratadine were observed in clinical trials. There was no effect of food or grapefruit juice on the disposition of Desloratadine.
Inhibitors of CYP3A4: In controlled clinical studies co-administration of desloratadine with ketoconazole, erythromycin or azithromycin resulted in increase plasma concentrations of desloratadine and 3-Hydroxydesloratadine, but there were no clinically relevant changes in the safety profile of desloratadine.
Fluoxetine: In controlled clinical studies co-administration of desloratadine with fluoxetine resulted in increase plasma concentrations of desloratadine and 3-Hydroxydesloratadine, but there were no clinically relevant changes in the safety profile of desloratadine.
Cimetidine: In controlled clinical studies co-administration of desloratadine with cimetidine resulted in increase plasma concentrations of desloratadine and 3-Hydroxydesloratadine, but there were no clinically relevant changes in the safety profile of desloratadine.
